反応 #11334

反応方程式

5-(4-fluorobenzyl)-2-furan carboxylic acid

thionylchloride

→

5-(4-fluorobenzyl)-2-furan carboxylic acid chloride

収率 100.6%

溶媒

DMF

反応条件

後処理

1. 1
   その他The excess amount of thionylchloride was evaporated
2. 2
   洗浄The precipitated residue was washed with n-hexane

実験手順

To 5-(4-fluorobenzyl)-2-furan carboxylic acid (450 mg, 2 mmol) were added thionylchloride (1 ml, 13.7 mmol) and DMF (0.025 ml). The mixture was stirred for 30 minutes at room temperature. The excess amount of thionylchloride was evaporated. The precipitated residue was washed with n-hexane to give crude 5-(4-fluorobenzyl)-2-furan carboxylic acid chloride (480 mg). NMR(CDCl3) δ: 4.03(2H, s), 6.20(1H, d, J=3.6 Hz), 7.03(2H, t, J=8.7 Hz), 7.19-7.24(2H, m), 7.42(1H, d, J=3.6 Hz).

出典