反応 #11332

反応方程式

benzenesulfonylchloride

sodium hydride

pyrrole

→

1-benzenesulfonylpyrrole

溶媒

DMF

DMF

DMF

反応条件

後処理

1. 1
   温度cooled again
2. 2
   workup.STIRRINGThe mixture was stirred for 30 minutes at room temperature
3. 3
   抽出extracted with ethylacetate
4. 4
   洗浄The extract was washed with water
5. 5
   その他dried
6. 6
   その他The solvent was evaporated
7. 7
   洗浄The obtained crystal was washed with hexane

実験手順

To a suspension of sodium hydride (60% in mineral oil, 2.4 g, 60 mmol) in DMF (100 ml) was added dropwise at an ice bath temperature a solution of pyrrole (3.35 g, 50 mmol) in DMF (5 ml). The mixture was stirred for 30 minutes at room temperature and cooled again. To the mixture was added dropwise a soluton of benzenesulfonylchloride (9.7 g, 5.5 mmol) in DMF (3 ml). The mixture was stirred for 30 minutes at room temperature and poured into ice-water, and extracted with ethylacetate. The extract was washed with water and dried. The solvent was evaporated. The obtained crystal was washed with hexane to give 1-benzenesulfonylpyrrole (8.4 g). Yield: 81%.

出典