反応 #1133043

反応方程式

ethyl 7-nitroindole-2-carboxylate

Lithium hydroxide hydrate

hydrochloric acid

→

title compound

7-Nitro-1H-indole-2-carboxylic acid

溶媒

tetrahydrofuran

water

反応条件

後処理

1. 1
   抽出the reaction mixture was extracted with ethyl acetate
2. 2
   乾燥The extract was dried over anhydrous magnesium sulfate
3. 3
   ろ過filtered
4. 4
   workup.DISTILLATIONThe filtrate was distilled under reduced pressure

実験手順

Commercially available ethyl 7-nitroindole-2-carboxylate (500 mg, 2.14 mmol) was dissolved in a solvent mixture of tetrahydrofuran and water (1:1, 20 mL). Lithium hydroxide hydrate (448 mg, 10.7 mmol) was added thereto, and the mixture was stirred for 8 h at room temperature. 1N-hydrochloric acid solution was added, and the reaction mixture was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, and filtered. The filtrate was distilled under reduced pressure to give the title compound.

出典