反応 #1124

反応方程式

hydrochloric acid

2-chloro-3-bromo-4-(cis-4-phenylcyclohexylamino)pyridine

sodium methoxide

water

→

2-Methoxy-3-bromo-4-(cis-4-phenylcyclohexylamino)pyridine

溶媒

dimethylformamide

methanol

反応条件

後処理

1. 1
   温度After cooling
2. 2
   抽出the reaction product is extracted with ethyl acetate
3. 3
   その他For purification it
4. 4
   その他is chromatographed

実験手順

2.21 g (6.04 mmol) of 2-chloro-3-bromo-4-(cis-4-phenylcyclohexylamino)pyridine in 30 ml of dimethylformamide are treated with 4.31 ml of 30% strength solution of sodium methoxide in methanol and the mixture is heated at 80° C. for 1 hour. After cooling, water is added, the mixture is adjusted to pH 8 using 1/2 conc. hydrochloric acid and the reaction product is extracted with ethyl acetate. For purification it is chromatographed. Yield: 1.72 g (79%); Rf =0.4 (diisopropyl ether)

出典