反応 #1121785

反応方程式

Methyl(6-(Benzyloxy)purin-9-yl)acetate

NaOH

HCl

→

(6-(Benzyloxy)purin-9-yl)acetic acid

溶媒

methanol

反応条件

後処理

1. 1
   その他The precipitate was separated from the mixture by filtration
2. 2
   洗浄washed with water and ether

実験手順

Methyl(6-(Benzyloxy)purin-9-yl)acetate (2.10 g; 7.0 mmol) was dissolved in methanol (70 ml) and 0.1 M NaOH (85 ml) is added. After 15 min. the pH of the reaction mixture was lowered by addition of 0.1 M HCl (˜80 ml) to pH 3. The precipitate was separated from the mixture by filtration and washed with water and ether. Yield: 1.80 g (90.2%). 1H-NMR (DMSO-d6): 8.55 (1H, s); 8.37 (1H, s); 7.55-7.30 (5H, m); 5.64 (2H, s); 5.09 (2H, s).

出典