反応 #1121756

反応方程式

2-Hydroxycarbonylmethyl-4-tetrahydropyranyloxy-2-cyclopenten-1-one

2-naphthol

1,3-dicyclohexylcarbodiimide

→

title compound

2-(2-Naphthyloxycarbonylmethyl)-4-hydroxy-2-cyclopenten-1-one

溶媒

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   ろ過The precipitate was filtered off
2. 2
   洗浄The filtrate was washed with 20 ml of diluted hydrochloride solution, water
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   ろ過filtered
5. 5
   その他evaporated under vacuum
6. 6
   workup.DISSOLUTIONThe crude product was dissolved in 30 ml acetone
7. 7
   workup.ADDITION6 ml water, further added with 0.3 g p-toluenesulfonic acid
8. 8
   workup.STIRRINGstirred overnight
9. 9
   その他Upon completion of the reaction, acetone
10. 10
    その他was evaporated
11. 11
    workup.ADDITIONthe reaction mixture was diluted with ethyl acetate
12. 12
    洗浄washed with an aqueous sodium bicarbonate solution
13. 13
    ろ過dehydration, filtration, and evaporation, and purification by chromatography on silica gel

実験手順

5 g of 2-Hydroxycarbonylmethyl-4-tetrahydropyranyloxy-2-cyclopenten-1-one (21 mmol) obtained from Example 5, 2-naphthol (4.7 g, 32 mmol), dichloromethane (50 ml), and 0.2 g 4-(dimethylamine)pyridine were added together to a 50 ml dichloromethane solution containing 1,3-dicyclohexylcarbodiimide (7 g, 34 mmol). The reaction mixture was stirred at room temperature for about 4 hours. The precipitate was filtered off. The filtrate was washed with 20 ml of diluted hydrochloride solution, water, dried over anhydrous magnesium sulfate, filtered, and evaporated under vacuum. The crude product was dissolved in 30 ml acetone and 6 ml water, further added with 0.3 g p-toluenesulfonic acid and stirred overnight. Upon completion of the reaction, acetone was evaporated and the reaction mixture was diluted with ethyl acetate and washed with an aqueous sodium bicarbonate solution and a brine solution. The organic liquid was subjected to the previous work-up procedure, including dehydration, filtration, and evaporation, and purification by chromatography on silica gel to obtain the title compound as white solid. MP: 81° C. (4.2 g, 71%) 1H-NMR (CDCl3/TMS): δ 7.82 (m,2H), 7.78 (d, 1H), 7.55 (m,2H), 7.46 (m,2H), 7.21 (dd, 1H), 5.04 (m, 1H), 3.56 (s, 2H), 2.89 (dd, 1H), 2.38 (dd, 1H), 1.60 (brs, 1H).

出典