反応 #1121752

ord-7a302eaf53494bc18899a86728c391f3

反応方程式

CCOC(=O)C[C@H](CC(C)C)C[N+](=O)[O-]
(S)-5-methyl-3-nitromethyl-hexanoic acid ethyl ester
[K+].[OH-]
KOH
[K+].[OH-]
KOH
→
CC(C)C[C@@H](CC(=O)[O-])C[N+](=O)[O-].CC(C)C[C@@H](CC(=O)[O-])C[N+](=O)[O-].[K+].[K+]
title compound
CC(C)C[C@@H](CC(=O)[O-])C[N+](=O)[O-].CC(C)C[C@@H](CC(=O)[O-])C[N+](=O)[O-].[K+].[K+]
(S)-5-Methyl-3-nitromethyl-hexanoic acid dipotassium salt

反応物

CCOC(=O)C[C@H](CC(C)C)C[N+](=O)[O-]
(S)-5-methyl-3-nitromethyl-hexanoic acid ethyl ester
[K+].[OH-]
KOH
[K+].[OH-]
KOH

試薬

なし

溶媒

O
H2O

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他The solvent was removed under reduced pressure
  2. 2
    その他to give a solid

実験手順

830 mg of (S)-5-methyl-3-nitromethyl-hexanoic acid ethyl ester (VIII, R1=ethyl) were suspended in 0.8 mL of H2O. 900 mg of 50% aqueous KOH were added. After 5 h at 25° C. conversion was complete (determination by HPLC). The solvent was removed under reduced pressure to give a solid consisting of the title compound and minor amounts of KOH.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08546112B2uspto-grants-2013_10