反応 #1121743

反応方程式

Boc-threonine

glycine ethyl ester hydrochloride

triethylamine

N,N′-dicyclohexylcarbodiimide

hydroxybenzotriazole

→

Boc-Thr-Gly-OEt

収率 85.4%

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他the mixture was reacted at room temperature for overnight
2. 2
   その他After completion of the reaction, reaction mixture
3. 3
   ろ過was filtered
4. 4
   抽出the filtrate was extracted with ethyl acetate
5. 5
   濃縮The extract was concentrated under reduced pressure
6. 6
   その他the product was crystallized from hexane

実験手順

Boc-threonine (produced by Wako Pure Chemical Industries Ltd.) (11.0 g, 50 mmol) and glycine ethyl ester hydrochloride (produced by Wako Pure Chemical Industries Ltd.) (8.4 g, 60 mmol) were dissolved in dichloromethane (250 mL). After triethylamine (8.4 mL, 60 mmol), N,N′-dicyclohexylcarbodiimide (DCC, 12.4 g, 60 mmol) and hydroxybenzotriazole (9.2 g, 60 mmol) were further added thereto, the mixture was reacted at room temperature for overnight with stirring. After completion of the reaction, reaction mixture was filtered, and then the filtrate was extracted with ethyl acetate. The extract was concentrated under reduced pressure, and the product was crystallized from hexane, to obtain Boc-Thr-Gly-OEt (1) (13.0 g) (yield; 85.1%).

出典