反応 #1121718

反応方程式

acetophenone

4-tert-butylbenzoyl chloride

→

1-phenylvinyl 4-tert-butylbenzoate

収率 57.0%

溶媒

water

反応条件

後処理

1. 1
   workup.WAITThe mixture was then left
2. 2
   温度to cool
3. 3
   抽出extracted with dichloromethane
4. 4
   乾燥The organic phase was dried over magnesium sulfate
5. 5
   その他the solvent was removed under reduced pressure
6. 6
   その他A 2.12 g sample was purified by flash chromatography (hexane:dichloromethane 3:1)

実験手順

A mixture of 4.16 g (21.62 mmol) of acetophenone trimethylsilylenol, 4.33 g (22.01 mmol) of 4-tert-butylbenzoyl chloride and 136 mg of mercuric chloride was heated at 100° C. for 2 h. The mixture was then left to cool, water was added over the reaction crude and extracted with dichloromethane. The organic phase was dried over magnesium sulfate and the solvent was removed under reduced pressure. A 2.12 g sample was purified by flash chromatography (hexane:dichloromethane 3:1) giving 1.17 g of 1-phenylvinyl 4-tert-butylbenzoate. Yield 57%.

出典