反応 #1121716

反応方程式

hydroquinone

1,6-dibromo hexane

Potassium hydroxide

→

4-(6-bromohexyloxy)phenol

収率 39.4%

溶媒

methanol

反応条件

後処理

1. 1
   その他fluxed at 60° C.
2. 2
   その他(Celsius) overnight
3. 3
   その他is lowered to a room temperature
4. 4
   その他methanol was evaporated from the reaction mixture
5. 5
   抽出Then, the reaction mixture was extracted three times with water (100 ml (milliliters)) and ethyl acetate (100 ml (milliliters))
6. 6
   その他Water was removed over magnesium sulfate
7. 7
   その他the solvents were evaporated
8. 8
   その他the resulting reaction mixture
9. 9
   その他was purified

実験手順

As shown in the following Scheme, hydroquinone (1) (4.5 g (grams)) and 1,6-dibromo hexane (2) (10 g (grams)) were dissolved in methanol (100 ml (milliliters)) at a room temperature. Potassium hydroxide (2.3 g (grams)) was added to the resulting mixture solution, and then fluxed at 60° C. (Celsius) overnight. Next day, the temperature of the reaction mixture is lowered to a room temperature, and methanol was evaporated from the reaction mixture. Then, the reaction mixture was extracted three times with water (100 ml (milliliters)) and ethyl acetate (100 ml (milliliters)). Water was removed over magnesium sulfate, and the solvents were evaporated, and the resulting reaction mixture was purified using a column chromatography (developer solution: ethylacetate/hexane=1/5 volume ratio) to obtain 4.4 g (grams) of 4-(6-bromohexyloxy)phenol (3).

出典