反応 #1120

反応方程式

4-ethyl-4-amino-5-bromopyridine

4-(1,1,3,3-tetramethylbutyl)cyclohexanone

diisopropyl ether

→

2-Ethyl-4-[cis-4-(1,1,3,3-tetramethylbutyl)cyclohexylamino]-5-bromopyridine

反応条件

実験手順

As Example 75, but using 2.01 g (10 mmol) of 4-ethyl-4-amino-5-bromopyridine instead of 2-ethyl-3-bromo-4-aminopyridine and 4.2 g (20 mmol) of 4-(1,1,3,3-tetramethylbutyl)cyclohexanone instead of 4-phenylcyclohexanone. Yield: 1.9 g (48%); Rf =0.39 (diisopropyl ether)

出典