反応 #1119556

反応方程式

4-chloro-1-hydroxypyrazole

potassium hydroxide

methyl α-(2-bromomethylphenyl)-β-methoxyacrylate

→

title compound

収率 77.5%

Methyl α-[2-(4-chloro-1-pyrazolyloxymethyl)phenyl]-β-methoxyacrylate

収率 77.5%

溶媒

ethanol

ethanol

dimethylformamide

反応条件

後処理

1. 1
   濃縮concentrated
2. 2
   workup.STIRRINGThe mixture is stirred at 100° C. for two hours
3. 3
   その他a solvent is removed under reduced pressure
4. 4
   洗浄The organic phase is washed with water
5. 5
   その他dried
6. 6
   濃縮concentrated

実験手順

2.4 g (0.02 mol) of 4-chloro-1-hydroxypyrazole in 30 ml of ethanol are added dropwise to a solution of 1.2 g (0.02 mol) of potassium hydroxide in 50 ml of ethanol. The reaction mixture is stirred at room temperature for two hours and then concentrated. The residue is taken up in 60 ml of dimethylformamide, and 5.7 g (0.02 mol) of methyl α-(2-bromomethylphenyl)-β-methoxyacrylate in 30 ml of dimethylformamide are added. The mixture is stirred at 100° C. for two hours, a solvent is removed under reduced pressure and the residue is taken up in methyl tertbutyl ether. The organic phase is washed with water, dried and concentrated. 5.0 g (77%) of the title compound are obtained as an oil (compound no. 9).

出典