反応 #1116

反応方程式

sodium bicarbonate

3,4-dichloro-2-ethylpyridine

4-(2,4-dichlorobenzylidene)cyclohexylamine

ammonium chloride

→

3-Chloro-4-[4-(2,4-dichlorobenzylidene)cyclohexyl]amino-2-ethylpyridine

収率 7.0%

溶媒

N-methylpyrrolidone

反応条件

後処理

1. 1
   温度After cooling
2. 2
   抽出extracted with ethyl acetate
3. 3
   その他The product is purified by chromatography on silica gel

実験手順

1.6 g of 3,4-dichloro-2-ethylpyridine and 2.5 g of 4-(2,4-dichlorobenzylidene)cyclohexylamine are heated at 180° C. for 3.5 hours together with 55 g of ammonium chloride in 9 ml of N-methylpyrrolidone. After cooling, the mixture is poured into saturated sodium bicarbonate solution and extracted with ethyl acetate. The product is purified by chromatography on silica gel using ethyl acetate/heptane 1:4. Yield: 7%

出典