反応 #1113089

反応方程式

4-(2,5-dichloro-phenoxy)-pyrimidine-5-carboxylic acid

1-methyl-1,2,3,4-tetrahydroquinoxaline

Metina

→

desired compound

収率 8.0%

[4-(2,5-Dichloro-phenoxy)-pyrimidin-5-yl]-(4-methyl-3,4-dihydro-2H-quinoxalin-1-yl)-methanone

収率 8.0%

反応条件

後処理

1. 1
   その他The compound was purified by preparative HPLC (Phenomenex Gemini column)

実験手順

The title compound was prepared in analogy to Example 77, from 4-(2,5-dichloro-phenoxy)-pyrimidine-5-carboxylic acid and 1-methyl-1,2,3,4-tetrahydroquinoxaline (commercially available, Metina, catalog number M-636). The compound was purified by preparative HPLC (Phenomenex Gemini column) using a gradient of acetonitrile:water (10:90 to 98:2) to give 6.5 mg (8%) of the desired compound. MS (ESI): m/z=415.1 [M+H]+.

出典