反応 #1111949

反応方程式

2,4-Dihydroxy benzoic acid

(2-piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester

→

required product

収率 38.2%

{2-[1-(2,4-Dihydroxy Benzoyl)piperidin-4-yl]ethyl}carbamic Acid Tert-butyl Ester

収率 38.2%

反応条件

実験手順

2,4-Dihydroxy benzoic acid (1.25 g, 8.11 mmol) and (2-piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester (1.85 g, 8.11 mmol) and other reagents as described in Example 9(e) were used to afford 1.13 g of the required product. 1H NMR (DMSO-d6): δ 1.05 (2H, m), 1.25 (2H, m), 1.4 (9H, s), 1.65 (2H, m), 2.75 (2H, m), 2.95 (2H, m), 3.15 (1H, m), 4.0 (2H, m), 6.24 (2H, m), 6.78 (1H, m), 6.9 (1H, d), 9.6 (2H, brs).

出典