反応 #1111924

反応方程式

3-(4-cyano phenoxy)-5-phenethyloxy benzoic acid

(2-piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester

→

required product

収率 58.2%

(2-{1-[3-(4-cyanophenoxy)-5-phenethyloxybenzoyl]piperidin-4-yl}ethyl)-carbamic Acid Tert-butyl Ester

収率 58.2%

反応条件

実験手順

Following the procedure of Example 5(c) 3-(4-cyano phenoxy)-5-phenethyloxy benzoic acid 0.6 g (1.66 mmol) and (2-piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester (0.378 g, 1.66 mmol) were used to afford 0.55 g of the required product. 1H NMR (DMSO-d6): δ 1.05 (3H, m), 1.4 (9H, s), 1.55 (2H, m), 1.7 (1H, m), 2.1 (5H, s), 3.0 (5H, m), 4.2 (2H, t), 4.4 (1H, m), 6.62 (1H, s), 6.78 (2H, s), 7.14 (2H, d), 7.24 (1H, m), 7.3 (4H, d), 7.88 (2H, d).

出典