反応 #1111887

反応方程式

6-(4-cyano phenoxy)-5-fluoro-2-(3-trifluoromethoxy phenoxy)nicotinic acid

(2-piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester

→

required product

収率 57.1%

(2-{1-[6-(4-cyano phenoxy)-5-fluoro-2-(3-trifluoromethoxy phenoxy)pyridine-3-carbonyl]piperidin-4-yl}ethyl)carbamic Acid Tert-butyl Ester

収率 57.1%

反応条件

実験手順

6-(4-cyano phenoxy)-5-fluoro-2-(3-trifluoromethoxy phenoxy)nicotinic acid (1.3 g, 2.99 mmol) and (2-piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester (0.684 g, 3.0 mmol) were coupled using the procedure of Example 5(c) to afford 1.1 g of the required product. 1HNMR (DMSO-d6): δ 1.2 (2H, m), 1.4 (9H, d), 1.5 (2H, m), 1.6 (2H, m), 2.2 (1H, m), 2.35 (1H, m), 3.0 (3H, m), 3.7 (1H, m), 4.45 (1H, m), 6.78 (1H, m), 7.18 (1H, m), 7.26 (2H, m), 7.32 (1H, s), 7.46 (1H, m), 7.76 (1H, m), 7.86 (1H, s), 8.1 (1H, m).

出典