反応 #1111884

反応方程式

2-(4-cyano phenoxy)-6-(4-trifluoromethoxy phenoxy)nicotinic acid

(2-Piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester

→

required product

収率 69.8%

(2-{1-[2-(4-cyanophenoxy)-6-(4-trifluoromethoxyphenoxy)pyridine-3-carbonyl]piperidin-4-yl}ethyl)carbamic Acid Tert-butyl Ester

収率 69.8%

反応条件

実験手順

2-(4-cyano phenoxy)-6-(4-trifluoromethoxy phenoxy)nicotinic acid (0.2 g, 0.48 mmol) and (2-Piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester (0.11 g, 0.48 mmol) were coupled using the procedure of Example 5(c) to afford 0.21 g of the required product. Percentage purity (LCMS): 68.11%.

出典