反応 #1111881

反応方程式

6-(4-cyano phenoxy)-2-(4-fluoro phenoxy)nicotinic acid

(2-piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester

→

required product

収率 78.2%

(2-{1-[6-(4-cyano phenoxy)-2-(4-fluoro phenoxy)pyridine-3-carbonyl]piperidin-4-yl}ethyl)carbamic Acid Tert-butyl Ester

収率 78.2%

反応条件

実験手順

6-(4-cyano phenoxy)-2-(4-fluoro phenoxy)nicotinic acid (0.2 g, 0.57 mmol) and (2-piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester (0.13 g, 0.57 mmol) were coupled using the procedure of Example 5(c) to afford 0.25 g of the required product. Percentage purity: LCMS (−ve mode): 67.5%.

出典