反応 #1111879

反応方程式

6-(4-Cyano phenoxy)-2-(4-trifluoromethoxy phenoxy)nicotinic acid

(2-piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester

→

required product

収率 66.5%

(2-{1-[6-(4-cyano phenoxy)-2-(4-trifluoromethoxy phenoxy)pyridine-3-carbonyl]piperidin-4-yl}ethyl)carbamic Acid Tert-butyl Ester

収率 66.5%

反応条件

実験手順

6-(4-Cyano phenoxy)-2-(4-trifluoromethoxy phenoxy)nicotinic acid (0.15 g, 0.36 mmol) and (2-piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester (0.082 g, 0.36 mmol) were coupled using the procedure of Example 5(c) to afford 0.15 g of the required product. Percentage purity (LCMS): 43.23%.

出典