反応 #1111876

反応方程式

2-(4-cyano phenoxy)-6-isopropoxy isonicotinic acid

(2-piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester

→

required product

収率 35.2%

(2-{1-[2-(4-cyano-phenoxy)-6-isopropoxy-pyridine-4-carbonyl]piperidin-4-yl}ethyl)-carbamic Acid Tert-Butyl Ester

収率 35.2%

反応条件

実験手順

2-(4-cyano phenoxy)-6-isopropoxy isonicotinic acid (0.20 g, 0.67 mmol) and (2-piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester (0.16 g, 0.7 mmol) were coupled using the procedure of Example 5(c) to afford 0.12 g of the required product. 1H NMR (DMSO-d6): δ 1.12 (2H, m), 1.15 (6H, d), 1.4 (9H, s), 1.6 (2H, m), 1.75 (1H, m), 2.7 (1H, m), 2.98 (3H, m), 3.5 (1H, m), 4.45 (1H, m), 4.8 (1H, m), 6.48 (1H, s), 6.58 (1H, s), 6.8 (1H, brs), 7.38 (2H, d), 7.9 (2H, d).

出典