反応 #1111760

反応方程式

2-(1-azidopropyl)pyrazine

PPh3

MeOH

MeOH

→

title compound

1-(Pyrazin-2-yl)propan-1-amine

溶媒

THF

water

反応条件

後処理

1. 1
   workup.WAITleft
2. 2
   ろ過The mixture was filtered under vacuum
3. 3
   洗浄rinsed with DCM (a precipitate
4. 4
   その他formed
5. 5
   その他The filtrate was evaporated

実験手順

The 2-(1-azidopropyl)pyrazine (56 mg) was dissolved in the THF (5 ml) and water (1 ml) and the PS—PPh3 (225 mg) added. The reaction mixture was heated to 50° C. and left to stir for approx. 20 hours. The mixture was filtered under vacuum and rinsed with DCM (a precipitate formed and re-dissolved with MeOH) then MeOH. The filtrate was evaporated to yield the title compound as a yellow oil which was used without further purification. [M+H]+ 138.

出典