反応 #1107598

反応方程式

methyl 3-bromo-2-(bromomethyl)benzoate

methyl 6-aminohexanoate hydrochloride

triethylamine

→

title compound

収率 99.0%

methyl 6-(4-bromo-1-oxoisoindolin-2-yl)hexanoate

収率 99.0%

溶媒

THF

反応条件

実験手順

The procedure of the step 2 in Example 1 was repeated except that methyl 3-bromo-2-(bromomethyl)benzoate instead of methyl 3-bromo-2-(bromomethyl)-4,5-dimethoxybenzoate, methyl 6-aminohexanoate hydrochloride instead of methyl 4-(aminomethyl)benzoate hydrochloride, triethylamine (2.4 equiv.), and THF as a solvent were used and the reaction was conducted for 20 hrs, to obtain the title compound (99%).

出典