反応 #1107086

反応方程式

Potassium carbonate

thiophene-2-thiol

1,2-dibromoethane

→

2-(2-bromo-ethylsulfanyl)-thiophene

収率 95.0%

反応条件

後処理

1. 1
   その他Then potassium carbonate is removed by filtration
2. 2
   濃縮the mother liquid is concentrated
3. 3
   その他to give a crude that
4. 4
   その他is purified by column chromatography (silica gel, eluent: cyclohexane 100%)

実験手順

Potassium carbonate (2.50 g, 18.07 mmol, 2.1 eq) is added at room temperature to a stirred solution of thiophene-2-thiol (813 μL, 8.61 mmol, 1.0 eq) in 1,2-dibromoethane (10 mL) and the resulting mixture is stirred at 78° C. for 3 hours. Then potassium carbonate is removed by filtration and the mother liquid is concentrated to give a crude that is purified by column chromatography (silica gel, eluent: cyclohexane 100%) to afford 2-(2-bromo-ethylsulfanyl)-thiophene as a light yellow oil (1.86 g, 95% yield).

出典