反応 #1107

反応方程式

4-(4-tert-butylanilino)-3-methoxy-2-methylpyridine

→

4-(4-tert-Butylcyclohexylamino)-3-methoxy-2-methylpyridine

溶媒

water

methanol

HCl

反応条件

後処理

1. 1
   その他are hydrogenated at room temperature
2. 2
   その他normal pressure until absorption of hydrogen
3. 3
   ろ過After filtering
4. 4
   濃縮concentrating 1 g of syrup

実験手順

1 g of 4-(4-tert-butylanilino)-3-methoxy-2-methylpyridine in 20 ml of methanol, 3.7 ml of 2N HCl and 1.3 ml of water are hydrogenated at room temperature and normal pressure until absorption of hydrogen has ended using 1 g of rhodium on alumina (5% strength). After filtering and concentrating 1 g of syrup remains=100% isomer mixture.

出典