反応 #1106678

反応方程式

((3,4-Dihydro-2H-benzo[b][1,4]dioxepin-3-yl)methyl)amine

sulfamide

Chloroform

→

title compound

((3,4-Dihydro-2H-benzo[b][1,4]dioxepin-3-yl)methyl)sulfamide

溶媒

dioxane

反応条件

後処理

1. 1
   温度heated
2. 2
   温度to reflux overnight
3. 3
   その他the precipitate was removed by filtration
4. 4
   濃縮The filtrate was concentrated under vacuum
5. 5
   その他purified by chromatography (2% to 8% acetone in dichloromethane)

実験手順

((3,4-Dihydro-2H-benzo[b][1,4]dioxepin-3-yl)methyl)amine (2.90 g, 16.2 mmol) and sulfamide (3.11 g, 32.4 mmol) were combined in dry dioxane (60 ml) and heated to reflux overnight. Chloroform was added and the precipitate was removed by filtration. The filtrate was concentrated under vacuum and purified by chromatography (2% to 8% acetone in dichloromethane) to yield the title compound as an off-white solid.

出典