反応 #1106675

反応方程式

3-bromo-5-tert-butylbenzaldehyde

malonic acid

ammonium acetate

→

product

収率 51.6%

3-amino-3-(3-bromo-5-tert-butylphenyl)propionic acid

収率 51.6%

溶媒

isopropanol

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度at reflux under nitrogen for 3 h
3. 3
   その他to afford a thick colorless solid
4. 4
   ろ過The solid was filtered hot
5. 5
   洗浄washed with hot isopropanol (2×25 mL)
6. 6
   その他dried in vacuo

実験手順

A suspension of 3-bromo-5-tert-butylbenzaldehyde (4.17 g, 17.30 mmol), malonic acid (2.15 g, 20.72 mmol) and ammonium acetate (2.66 g, 34.59 mmol) in isopropanol (35 mL) was heated at reflux under nitrogen for 3 h to afford a thick colorless solid. The solid was filtered hot, washed with hot isopropanol (2×25 mL) and dried in vacuo to give the desired racemic product as a colorless solid (2.68 g).

出典