反応 #1106664

反応方程式

1,2,3,4-tetrafluoro-5,8-dihydroxyanthraquinone

N,N-dimethylethylenediamine

→

Compound 1

1,4-bis(2-(dimethylamino)ethylamino)-2,3-difluoro-5,8-dihydroxyanthracene-9,10-dione

溶媒

CH2Cl2

反応条件

後処理

1. 1
   その他After evaporation of the solvents
2. 2
   その他the residue was purified by silica gel chromatography

実験手順

A mixture of 1,2,3,4-tetrafluoro-5,8-dihydroxyanthraquinone (1.0 g, 3.2 mmol) and N,N-dimethylethylenediamine (3 mL) in CH2Cl2 (30 mL) was stirred at room temperature for 12 hours. After evaporation of the solvents, the residue was purified by silica gel chromatography using isocratic solvent system of EtOAc/MeOH/Et3N (10:10:1) yielding 830 mgs of Compound 1 as dark blue product. Abs (max, PBS pH 7.4)=568 nm; Em=675 nm. The structure of Compound 1 is given below:

出典