反応 #1106633

反応方程式

2-hydroxyacetophenone

4,5-dimethylfuran-2-carbaldehyde

NaOCH3

→

chalcone

収率 58.2%

溶媒

THF

反応条件

実験手順

2.0 g (14.7 mmol) of 2-hydroxyacetophenone, 1.75 g of 4,5-dimethylfuran-2-carbaldehyde (14.1 mmol), and 10 ml of 25% wt NaOCH3 were reacted in 50 ml of dry THF to give 1.71 g (50%) of chalcone after purification. 1H NMR (300 MHz, CDCl3): δ 13.07 (s, 1H), 7.95 (d, J=7.8 Hz, 1H), 7.61 (d, J=15.0 Hz, 1H), 7.51-7.42 (m, 2H), 7.02 (d, d, J=0.9, 8.4 Hz, 1H), 6.94 (d, d, d, J=1.2, 8.4, 9.0 Hz, 1H), 6.60 (s, 1H), 2.34 (s, 3H), 2.00 (s, 3H).

出典