反応 #1106622

反応方程式

2-Acetylpyridine

KOH

NH4OH

ethyl alcohol

→

ter-pyridine

反応条件

後処理

1. 1
   その他6-(2-(4-Iodophenyl)ethynyl)pyridine-3-ter-pyridine (Compound 94, Scheme 24) was prepared
2. 2
   温度reflux for 14 hours
3. 3
   ろ過Thereafter the crude solid was collected by filtration
4. 4
   洗浄washed with cold EtOH

実験手順

6-(2-(4-Iodophenyl)ethynyl)pyridine-3-ter-pyridine (Compound 94, Scheme 24) was prepared by stirring a mixture of Compound 93 (500 mg, 1.5 mmol), 2-Acetylpyridine (550 mg, 4.5 mmol), KOH 85% (360 mg, 4.5 mmol, and NH4OH 29% (7.5 ml, 6 mmol) in anhydrous ethyl alcohol (25 ml) and reflux for 14 hours. Thereafter the crude solid was collected by filtration, and washed with cold EtOH to produce the ter-pyridine Compound 94 as a brownish solid (65% yield).

出典