反応 #11063

反応方程式

intermediate 16a

(S)-[imino-(4-{[(3-methanesulfonylamino-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carbonyl)-amino]-methyl)-phenyl)-methyl]-carbamic acid tert-butyl ester

intermediate 1j

(S)-[(4-{[(3-amino-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carbonyl)-amino]-methyl}-phenyl)-imino-methyl]-carbamic acid tert-butyl ester

benzene sulfonyl chloride

→

intermediate 17a

収率 80.1%

(S)-[imino-(4-{[(3-benzenesulfonylamino-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carbonyl)-amino]-methyl}-phenyl)-methyl]-carbamic acid tert-butyl ester

収率 80.1%

反応条件

実験手順

Following a procedure similar to that for the preparation of intermediate 16a, intermediate 1j (50 mg, 0.117 mmol) and benzene sulfonyl chloride (22.8 mg, 0.129 mmol) yielded 53.6 mg (80.1%) of intermediate 17a. MS (ESI) 567.0 (M+H+).

出典