反応 #1105

反応方程式

HCl

magnesium

octyl bromide

THF

4-(4-oxocyclohexylamino)-3-methoxy-2-methylpyridine

THF

→

4-[(4-Hydroxy-4-n-octyl)cyclohexylamino]-3-methoxy-2-methylpyridine

反応条件

後処理

1. 1
   workup.DISTILLATIONThe THF is then distilled off in vacuo at room temperature
2. 2
   抽出the product is extracted from the solution which

実験手順

The Grignard solution is prepared from 0.73 g of magnesium and 6.0 g of octyl bromide in 50 ml of absolute THF. 2.8 g of 4-(4-oxocyclohexylamino)-3-methoxy-2-methylpyridine in 20 ml of THF are added dropwise to the solution. After 2 hours the mixture is acidified with 2N HCl. The THF is then distilled off in vacuo at room temperature and the product is extracted from the solution which is rendered alkaline with methylene chloride. Further working up takes place as in the previous working procedure.

出典