反応 #11044

反応方程式

Methyl (2S)-3-(3′-amino[1,1′-biphenyl]-4-yl)-2-mesitylsulfonylamino-propanoate

3,4-diethoxy-3-cyclobuten-1,2-dion

→

title compound

収率 59.0%

Methyl (2S)-3-{3′-[(2-ethoxy-3,4-dioxo-1-cyclobuten-1-yl)-amino][1,1′-biphenyl]-4-yl}-2-mesitylsulfonylamino-propanoate

収率 59.0%

溶媒

1 propanol

反応条件

後処理

1. 1
   温度refluxed for 20 h
2. 2
   その他Purification by flash chromatography (dichloromethane/acetic acid ethyl ester 10+1)

実験手順

2 g of Methyl (2S)-3-(3′-amino[1,1′-biphenyl]-4-yl)-2-mesitylsulfonylamino-propanoate 12.1.2 were mixed with 0.75 g 3,4-diethoxy-3-cyclobuten-1,2-dion in 40 ml 1 propanol and refluxed for 20 h. Purification by flash chromatography (dichloromethane/acetic acid ethyl ester 10+1) yielded 1,5 g of the title compound.

出典