反応 #1102

反応方程式

water

4-(4-oxocyclohexylamino)-3-methoxy-2-methylpyridine

O-benzylhydroxylamine

ethyl acetate methanol

water

→

4-[4-(O-Benzyloximino)cyclohexylamino]-3-methoxy-2-methylpyridine

溶媒

toluene

反応条件

実験手順

2 g of 4-(4-oxocyclohexylamino)-3-methoxy-2-methylpyridine and 1.2 g O-benzylhydroxylamine are boiled in toluene in a water separator until liberation of water has ended. The product is isolated by column chromatography (ethyl acetate/methanol 9:1; silica gel). 1.8 g=53%

出典