反応 #10965

反応方程式

Allyl 3-amino-2-(2-methyl-[1,3]dioxolan-2-yl)propionate

3-fluorophthalic anhydride

→

desired product

収率 52.0%

Allyl 3-(4-fluoro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate

収率 52.0%

溶媒

chloroform

反応条件

後処理

1. 1
   workup.ADDITIONafter adding
2. 2
   その他the solvent was evaporated
3. 3
   workup.DISTILLATIONby distilling under a reduced pressure
4. 4
   その他The residue was purified

実験手順

Allyl 3-amino-2-(2-methyl-[1,3]dioxolan-2-yl)propionate (400 mg, 1.86 mmol) was dissolved in 10 mL of chloroform, and 3-fluorophthalic anhydride (401 mg, 2.42 mol) was added to the obtained solution. The resulting mixture was then refluxed at 80° C. for 3 days after adding. After the reaction was completed, the solvent was evaporated by distilling under a reduced pressure. The residue was purified by performing column chromatography (eluent: n-hexane/ethyl acetate=3/1) to obtain the desired product as a white solid (351 mg, 52%). Rf=0.29 (eluent: n-hexane/ethyl acetate=2/1)

出典