反応 #1095852

反応方程式

4-(2-butynyloxy)-6-chloro-5-fluoropyrimidine

2-methylpyperidine

→

4-(2-butynyloxy)-5-fluoro-6-(2-methylpiperidino)pyrimidine

収率 71.1%

溶媒

ethanol

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   温度under reflux condition
3. 3
   濃縮concentrated

実験手順

Into 3 ml of ethanol was resolved 0.3 g of 4-(2-butynyloxy)-6-chloro-5-fluoropyrimidine, 0.45 g of 2-methylpyperidine was added therein, and the mixture was stirred for 5 hours under reflux condition. The reaction mixture was cooled to near room temperature and concentrated. The residue was subjected to silica gel column chromatography to obtain 0.28 g of 4-(2-butynyloxy)-5-fluoro-6-(2-methylpiperidino)pyrimidine (hereinafter, referred to as Compound (1)).

出典