反応 #1095472

反応方程式

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid

toluene

10-Camphorsulfonic acid

→

2-(2-methoxy-2-phenyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid

溶媒

trimethyl orthobenzoate

ethyl acetate

反応条件

後処理

1. 1
   ろ過filtered through Celite
2. 2
   洗浄washed with brine
3. 3
   乾燥dried (Na2SO4)
4. 4
   その他purified by silica gel chromatography

実験手順

To a solution of (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid F-4 (300 mg, 1.58 mmol) and powdered molecular sieves (1 g) in trimethyl orthobenzoate (5 mL) and toluene (5 ml) was added 10-Camphorsulfonic acid (20 mg) and the reaction was heated at 110° C. under vacuum (20 torr) for 5 h. The solution was diluted with ethyl acetate, filtered through Celite and washed with brine, dried (Na2SO4) and then purified by silica gel chromatography to afford 1.2 mmol 2-(2-methoxy-2-phenyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid I-1 (40%).

出典