反応 #1093722

反応方程式

methyl 4-(2-phenylsulfonylamino-4-chlorophenoxy-methyl)benzoate

isopropyl iodide

water

HCl

→

title compound

Methyl 4-[2-(N-isopropyl-phenylsulfonylamino)-4-chlorophenoxymethyl]-benzoate

溶媒

DMF

potassium carbonate

反応条件

後処理

1. 1
   workup.ADDITIONwere added
2. 2
   抽出The mixture was extracted with ethyl acetate
3. 3
   洗浄The organic layer was washed
4. 4
   その他dried over,
5. 5
   濃縮concentrated
6. 6
   ろ過after filtration
7. 7
   洗浄washed

実験手順

To a solution of methyl 4-(2-phenylsulfonylamino-4-chlorophenoxy-methyl)benzoate (402 mg; prepared in Example 7(a)) in DMF (4 ml), potassium carbonate 256 (mg) and isopropyl iodide (185 μl) were added. The mixture was stirred overnight at room temperature and for 9 hours at 50° C. To the reaction solution, iced water and 2N HCl were added. The mixture was extracted with ethyl acetate. The organic layer was washed, dried over, concentrated after filtration, solidified with ethanol and washed to give the title compound (411 mg) having the following physical data.

出典