反応 #1093

反応方程式

N-tert-butyl-2-methoxycarbonyl-5-nitrobenzenesulfonamide

hydrogen

→

N-tert-Butyl-5-amino-2-methoxycarbonylbenzenesulfonamide

溶媒

MeOH

反応条件

後処理

1. 1
   その他The catalyst is separated off
2. 2
   その他the solvent is removed by distillation
3. 3
   その他to crystallize

実験手順

25.08 g (0.079 mol) of N-tert-butyl-2-methoxycarbonyl-5-nitrobenzenesulfonamide are dissolved in 1000 ml of MeOH. 0.50 g of Pd--C (10%) is added and the mixture is shaken under a hydrogen atmosphere (1 atm) until the uptake of hydrogen has finished. The catalyst is separated off and the solvent is removed by distillation. The residue is induced to crystallize by stirring with a little ethyl acetate. The resulting N-tert-butyl-5-amino-2-methoxycarbonylbenzenesulfonamide (18.3 g; 80.9% of theory) melts at 193° C.

出典