反応 #1076755

反応方程式

trityl chloride

Gly-Phe

→

Trt-Gly-Phe

収率 64.6%

溶媒

H2O

H2O

2-propanol

diethylamine

反応条件

後処理

1. 1
   その他to obtain a solution
2. 2
   その他To the resultant reaction mixture
3. 3
   その他The generated precipitate was collected
4. 4
   洗浄washed with water
5. 5
   workup.DISSOLUTIONdissolved into 5 ml of acetic acid
6. 6
   その他to thereby obtain an acidic solution
7. 7
   その他The obtained acidic solution was evaporated to dryness under reduced pressure

実験手順

Production of compound (22) was conducted in substantially the same manner as in step 1 of Example 6. That is, Gly-Phe (manufactured and sold by PEPTIDE INSTITUTE INC., Japan, 1.1 g, 5 mmol) was dissolved in a mixture of 2 ml of H2O, 2 ml of 2-propanol and 1.5 ml of diethylamine, to obtain a solution. To the obtained solution was portionwise added trityl chloride (1.8 g, 6.5 mmol), followed by stirring for one hour. To the resultant reaction mixture was added H2O, to thereby generate a precipitate. The generated precipitate was collected, washed with water and then dissolved into 5 ml of acetic acid, to thereby obtain an acidic solution. The obtained acidic solution was evaporated to dryness under reduced pressure, to thereby obtain 1.5 g of Trt-Gly-Phe.

出典