反応 #1074580

反応方程式

biphenyl-3,4-diamine

MeOH

water

cyanogen bromide

→

5-Phenyl-1H-benzoimidazol-2-ylamine

溶媒

THF

反応条件

後処理

1. 1
   その他The reaction was partitioned between EtOAc and aqueous sodium hydroxide
2. 2
   抽出the aqueous layer re-extracted with EtOAc

実験手順

To a solution of biphenyl-3,4-diamine (0.99 mmol) in THF:MeOH:water (5 mL:10 mL:10 mL) was added cyanogen bromide (5M solution in acetonitrile, 1.06 mmol). The resulting mixture was stirred at room temperature overnight. The reaction was partitioned between EtOAc and aqueous sodium hydroxide and the aqueous layer re-extracted with EtOAc.

出典