反応 #1071943

反応方程式

EtOH

NaOH

EtOH

2,5-dicarbethoxy-3,4-dihydroxythiophene

→

2,5-dicarboxy-3,4-dihydroxythiophene

溶媒

H2O

反応条件

後処理

1. 1
   温度refluxed under N for 20 h
2. 2
   その他was removed by distillation
3. 3
   workup.DISSOLUTIONthe residue was redissolved in H2O
4. 4
   その他was obtained This product
5. 5
   ろ過was collected by filtration
6. 6
   洗浄washed with cold H2O
7. 7
   その他then crystallized from dilute MeOH
8. 8
   その他to give colorless needles

実験手順

EtOH (30 mL) was added to 2,5-dicarbethoxy-3,4-dihydroxythiophene (1 g). A solution of NaOH (4.0 g) in H2O (20 mL) was added and refluxed under N for 20 h. Upon cooling to ambient temperature the EtOH was removed by distillation and the residue was redissolved in H2O then acidified with 15% HClaq when a white ppt was obtained This product was collected by filtration and washed with cold H2O then crystallized from dilute MeOH to give colorless needles.

出典