反応 #1069770

反応方程式

acetone

cis-1,2-cyclohexanedicarboxylic anhydride

2-hydroxyethyl methacrylate

→

2-[2-(methacryloyloxy)ethoxy-carbonyl]cyclohexanecarboxylic acid

溶媒

water

反応条件

後処理

1. 1
   温度This mixture was heated
2. 2
   温度with refluxing for 5 hours
3. 3
   workup.DISTILLATIONthe acetone was distilled off under reduced pressure
4. 4
   workup.ADDITIONThereafter, 1N hydrochloric acid (500 mL) and ethyl acetate (2,000 mL) were added to the residue
5. 5
   抽出to extract it
6. 6
   洗浄The resulting organic phase was washed twice with saturated aqueous sodium chloride solution (500 mL), and anhydrous magnesium sulfate (100 g)
7. 7
   workup.ADDITIONwas then added
8. 8
   その他Subsequently, the magnesium sulfate was removed by filtration
9. 9
   workup.DISTILLATIONthe ethyl acetate was distilled off under reduced pressure
10. 10
    その他to obtain a white solid
11. 11
    ろ過the particles were taken out by filtration
12. 12
    その他dried

実験手順

To acetone (1,000 mL) were added cis-1,2-cyclohexanedicarboxylic anhydride (308.3 g), 2-hydroxyethyl methacrylate (273.3 g), and 4-dimethylaminopyridine (4.9 g). This mixture was heated with refluxing for 5 hours, and the acetone was distilled off under reduced pressure. Thereafter, 1N hydrochloric acid (500 mL) and ethyl acetate (2,000 mL) were added to the residue to extract it. The resulting organic phase was washed twice with saturated aqueous sodium chloride solution (500 mL), and anhydrous magnesium sulfate (100 g) was then added thereto. This mixture was allowed to stand for 1 hour to dehydrate the organic phase. Subsequently, the magnesium sulfate was removed by filtration and the ethyl acetate was distilled off under reduced pressure to obtain a white solid. The solid was pulverized and then added to water (2,000 mL). After this mixture was stirred for 2 hours, the particles were taken out by filtration and dried. As a result, 2-[2-(methacryloyloxy)ethoxy-carbonyl]cyclohexanecarboxylic acid was obtained as a white solid (518.9 g).

出典