反応 #1069767

反応方程式

N,N-diethyl-p-nitrosoaniline

3-phenyl-1-(2-pyridyl)-5-aminopyrazole

→

7-diethylamino-3-phenyl-1-(2-pyridyl)-1H-pyrazolo[3,4-b]quinoxaline

収率 33.0%

溶媒

acetic acid

反応条件

後処理

1. 1
   濃縮The mixture was concentrated to half volume
2. 2
   workup.ADDITIONWater was added
3. 3
   その他to get a precipitate
4. 4
   ろ過filtered
5. 5
   その他The solid was purified by chromatograph column on silica gel
6. 6
   その他After removing the solvent

実験手順

1.78 g N,N-diethyl-p-nitrosoaniline and 2.67 g 3-phenyl-1-(2-pyridyl)-5-aminopyrazole were refluxed for 2 hrs in acetic acid. The mixture was concentrated to half volume. Water was added to get a precipitate, then filtered. The solid was purified by chromatograph column on silica gel. After removing the solvent, 1.3 g pure 7-diethylamino-3-phenyl-1-(2-pyridyl)-1H-pyrazolo[3,4-b]quinoxaline (DEPPPQ) was obtained as brown-red solid.

出典