反応 #1069763

反応方程式

NaOH

sodium

benzoylacetaldehyde

hydroxyamine chloride

→

benzoylacetonitrile

溶媒

ethanol

反応条件

後処理

1. 1
   温度The mixture was then refluxed for 24 hrs
2. 2
   濃縮concentrated to 2/3 volume
3. 3
   ろ過The precipitate was collected by filtration
4. 4
   その他dried under vacuum

実験手順

To a solution of 10 g sodium salt of benzoylacetaldehyde (prepared according to the procedure of Example 1) and 10 g hydroxyamine chloride in 30 ml ethanol was added 20 ml 50% NaOH at 0-10° C. The mixture was then refluxed for 24 hrs, and concentrated to 2/3 volume. The brown solution was neutralized with the concentrated hydrochloric acid. The precipitate was collected by filtration, and dried under vacuum to get a solid with slight pink color, 3.8 g benzoylacetonitrile.

出典