反応 #1069757

反応方程式

water

tartaric acid

hydrochloride

tiapride

→

Tiapride Hydrochloride

反応条件

後処理

1. 1
   その他Two granules are prepared
2. 2
   その他the granules obtained
3. 3
   その他are then dried
4. 4
   workup.ADDITIONThe other components, magnesium stearate, Aerosile® 200 and monosodium carbonate are then dry-added
5. 5
   workup.ADDITIONmixed
6. 6
   workup.ADDITIONFor granule 2, tiapride hydrochloride, Methocel® and Avicel® are dry-mixed
7. 7
   その他the granules obtained
8. 8
   その他are then dried
9. 9
   workup.ADDITIONMagnesium stearate and Aerosile® are dry-added
10. 10
    workup.ADDITIONmixed
11. 11
    その他3-layer tablets are prepared
12. 12
    workup.ADDITIONcontaining 250 mg of granule 1 in the first outer layer, 280 mg of granule 2 in the inner layer, which

実験手順

Two granules are prepared. For granule 1, Methocel® K100M, Avicel® PH102 and tartaric acid are dry-mixed and then granulated with water in a granulating blender and the granules obtained are then dried. The other components, magnesium stearate, Aerosile® 200 and monosodium carbonate are then dry-added and mixed. For granule 2, tiapride hydrochloride, Methocel® and Avicel® are dry-mixed and are then granulated with water in a granulating blender and the granules obtained are then dried. Magnesium stearate and Aerosile® are dry-added and mixed. 3-layer tablets are prepared, containing 250 mg of granule 1 in the first outer layer, 280 mg of granule 2 in the inner layer, which contains 100 mg of base tiapride in hydrochloride form, and 200 mg of granule 1 in the second outer layer.

出典