反応 #1069215

反応方程式

resultant compound

Ethyl 3-Formylindole-2-carboxylate

resultant compound

(Cyclohexyl)methyltriphenylphosphonium Bromide

benzyltriphenylphosphonium bromide

→

desired compound

収率 73.0%

Ethyl 3-(2-Phenylethenyl)indole-2-carboxylate

収率 73.0%

反応条件

実験手順

Using the procedure of Example 121 but replacing the resultant compound of Example 98 with the resultant compound of Example 97 and replacing the resultant compound of Example 120 with benzyltriphenylphosphonium bromide gave the desired compound in 73% yield after silica gel chromatography using 4:1 hexane/ethyl acetate. 1H NMR (CDCl3) δ 1.49 (t,J=7 Hz,3H), 4.48 (q,J=7 Hz,2H), 7.2-7.3 (m,2H), 7.35-7.45 (m,5H), 7.60 (br d,J=8 Hz,1H), 8.07 (d,J=16 Hz,1H), 8.16 (d,J=8 Hz,1H), 8.88 (br,1H). Mass spectrum: (M+H)+ =292.

出典