反応 #1064120

反応方程式

sodium nitrite

2,4-diamino-6-benzyloxy-pyrimidine

acetic acid

sodium nitrite

sodium nitrite

→

5-nitroso-2,4-diamino-6-benzyloxy-primidine

溶媒

H2O

反応条件

後処理

1. 1
   その他is held at 70°-80° C.
2. 2
   workup.ADDITIONis added dropwise
3. 3
   その他a positive reaction
4. 4
   温度The violet-red precipitate is cooled
5. 5
   その他recrystallized from ethanol or acetone
6. 6
   その他to yield 8

実験手順

To a solution of 16 g 2,4-diamino-6-benzyloxy-pyrimidine (7) in 250 mL of warm 30% acetic acid is added a solution of 7 g sodium nitrite in 25 mL H2O. The sodium nitrite solution is held at 70°-80° C. and is added dropwise while being stirred continuously. The sodium nitrite solution is added until potassium-iodate starch paper shows a positive reaction. The violet-red precipitate is cooled, suctioned off and then recrystallized from ethanol or acetone to yield 8.

出典