反応 #1061918

反応方程式

NaHCO3

1,8-Octanediol

dihydropyran

HCl

→

crude product

収率 99.8%

8-[(Tetrahydro-2H-pyran-2-yl)oxy]-1-octanol

収率 99.8%

反応条件

後処理

1. 1
   ろ過was filtered
2. 2
   その他Dichloromethane was removed with a rotary evaporator
3. 3
   その他the resulting residue was triturated with pentane
4. 4
   ろ過The solid was filtered from the pentane solution
5. 5
   その他the pentane was removed with a rotary evaporator

実験手順

1,8-Octanediol (16.8 g) (115 mmol) and 4.83 g of dihydropyran (57.5 mmol) in 1400 ml of dichloromethane containing 5 drops of concentrated HCl were stirred for 2 hours. Then 10 g of NaHCO3 were stirred in and the solution was filtered. Dichloromethane was removed with a rotary evaporator, and the resulting residue was triturated with pentane; the undissolved solid was 1,8-octanediol. The solid was filtered from the pentane solution, and the pentane was removed with a rotary evaporator to give 13.2 g (99.8%) of crude product oil.

出典