反応 #10588

反応方程式

Intermediate 2

N-(tert-butoxycarbonyl)-N′-[(5-isoquinolyl)sulfonyl]-N′-(3-phenylpropyl)-1,3-propylenediamine

hydrogen chloride methanol

→

title compound

N-[(5-isoquinolyl)sulfonyl]-N-(3-phenylpropyl)-1,3-propylenediamine hydrochloride

反応条件

後処理

1. 1
   温度under reflux
2. 2
   温度by heating
3. 3
   その他After the reaction
4. 4
   その他the solvent was evaporated under reduced pressure
5. 5
   その他the residue was crystallized from a mixed solvent of methanol and diethyl ether

実験手順

Intermediate 2 (913 mg) was added with 10% hydrogen chloride/methanol solution (18 ml, Tokyo Kasei Kogyo) at room temperature and stirred for 25 minutes under reflux by heating. After the reaction, the solvent was evaporated under reduced pressure, and the residue was crystallized from a mixed solvent of methanol and diethyl ether to obtain the title compound (653 mg).

出典